Combination therapeutics in complex diseases

Combination antifungal therapy without craniotomy in an immunocompromised patient with rhino-orbito-cerebral mucormycosis: A case report

Enhanced Therapeutic Benefit of QuercetinPhospholipid Complex in Carbon Tetrachloride-Induced Acute Liver Injury in Rats: A Comparative Study

Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absorption of quercetin when administered orally. To overcome this limitation, development of a value ...

The Role of Nanomedicine in Cell Based Therapeutics in Cancer and Inflammation

Cell based therapeutics is one of the most rapidly advancing medical fields, bringing together a range of fields including transplantation, tissue engineering and regeneration, biomaterials and stem cell biology. However, traditional cell-based therapeutics have many limitations, one of which is their harmful effects exhibited on healthy body cells due to their lack of specificity. Nanomedicine...

Multi-target therapeutics: when the whole is greater than the sum of the parts.

Drugs designed to act against individual molecular targets cannot usually combat multigenic diseases such as cancer, or diseases that affect multiple tissues or cell types such as diabetes and immunoinflammatory disorders. Combination drugs that impact multiple targets simultaneously are better at controlling complex disease systems, are less prone to drug resistance and are the standard of car...

Mesenchymal stem cells from umbilical cord tissue as potential therapeutics for cardiomyodegenerative diseases – a review

Heart failure is one of the leading causes of death worldwide. End stage disease often requires heart transplantation, which is hampered by donor organ shortage. Tissue engineering represents a promising alternative approach for cardiac repair. For the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. In this revi...